MAC DOCK 8.0 is a molecular modeling software that allows researchers to study molecular interactions. It provides a highly flexible interface for docking ligands into proteins and other larger structures. The software features robust algorithms for scoring, ligand flexibility, and binding site flexibility. It also offers a user-friendly interface making it accessible for experts and novices alike. With this version, users can perform Grid-Based Ligand Docking With Energetics (GLIDE) to accurately predict binding energies.