by David Posada

Modeltest is a model selection and model averaging software for phylogenetic inference.

Operating system: Windows

Publisher: David Posada

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ModelTest Software

ModelTest is a software package for model selection and model-based inference in phylogenetics. It is a powerful and efficient tool for selecting the best-fitting evolutionary model for a given dataset and analyzing the results of the model selection. ModelTest allows users to evaluate and compare a wide variety of evolutionary models, including likelihood-based and Bayesian approaches.

ModelTest enables users to quickly and accurately assess the best-fit model of evolution for their DNA/protein sequence data.

ModelTest offers a wide range of features and capabilities to assist users in model selection, model-based inference, and model comparison.

Model Selection: ModelTest provides a comprehensive set of evolutionary models for users to choose from. It includes models from both likelihood-based and Bayesian approaches. The software also allows users to customize their own models by adjusting parameters such as the base frequencies, rate ratios, and rate heterogeneity.

Model Evaluation: ModelTest provides a variety of ways to evaluate and compare models, including AIC, AICc, and BIC. The software also allows users to compare the relative performance of different models, allowing users to make more informed decisions.

Model-Based Inference: ModelTest provides a range of options for performing model-based inference, such as TreeSearch and TreeStat. The software also allows users to explore the effects of different evolutionary models on phylogenetic inference.

Model Comparison: ModelTest provides a variety of methods for comparing different models. These include likelihood ratio tests, Bayesian information criteria, and model selection statistics. The software also allows users to compare the performance of different models on a variety of datasets.

Data Visualization: ModelTest provides a range of visualization tools for exploring and analyzing the results of model selection and model-based inference. These include tree visualizations, heatmaps, and scatterplots. The software also allows users to export the results of their analyses in a variety of formats.

ModelSim: ModelTest includes a powerful simulation tool for testing and validating evolutionary models. This tool allows users to simulate datasets from a variety of evolutionary models, and to evaluate the performance of different models on the simulated datasets.

Documentation: ModelTest includes comprehensive documentation, including tutorials, user guides, and FAQs. The software also provides a range of support resources, including mailing lists, forums, and online help.


ModelTest is a comprehensive and powerful software package for model selection and model-based inference in phylogenetics. It provides a wide range of features and capabilities, including model selection, model evaluation, model-based inference, model comparison, data visualization, and ModelSim. The software also includes comprehensive documentation and support resources.
ModelTest software is a maximum likelihood-based program for assessing the best-fit model of molecular evolution. The software is available as a command-line program and requires certain technical requirements in order to run.

• Operating system: ModelTest software is compatible with Windows, MacOS, and Linux operating systems and requires the installation of either the Java Runtime Environment or OpenJDK.

• Memory: The program requires at least 512 MB of RAM but can use up to 4 GB for large datasets.

• Storage: ModelTest requires at least 500 MB of free disk space for installation and data storage.

• Processor: The program is multithreaded and requires a processor with at least two cores.

• Network: ModelTest can be run on a local machine or on a cluster, but in the latter case, a network connection is required.

• Software: ModelTest requires the installation of a compatible version of the PAUP* (Phylogenetic Analysis Using Parsimony) package.

Prioritizes models based on likelihood using various statistical methods.
Supports a wide range of evolutionary models.
Ease of use with comprehensive documentation.

Requires significant computing power for larger phylogenetic data sets.
Potential inconsistency in model selection among different datasets.
Steep learning curve for beginners.
image/svg+xmlBotttsPablo Stanley Körner Andrew Zeni
I have used the Modeltest software several times to compare models of nucleotide substitution. I found the program to be powerful and easy to use. It allows you to quickly carry out model selection and has a wide range of models. The output is also very informative and easy to understand. I was especially impressed by the ability to run multiple analyses at once and the graphical output. The software is generally reliable but can be slow to run on larger datasets. The documentation is also helpful and easy to follow.
image/svg+xmlBotttsPablo Stanley Körner Alexander Station
I recently tried Modeltest on a couple of datasets, and I found it to be quite user-frendly, but I had some difficulity interperting the resultts.
image/svg+xmlBotttsPablo Stanley Körner Alexander E.
This software is a tool for statistical analysis of DNA or protein sequence data. It employs various model selection techniques to determine the best-fit evolutionary model, which is then used to infer phylogenetic relationships among sequences. Modeltest offers various substitution models, including those that incorporate rate variation across sites, among others. The software also allows for hypothesis testing and comparison of models using likelihood ratio tests. Overall, Modeltest provides a powerful and versatile tool for researchers studying evolutionary relationships among sequences.
image/svg+xmlBotttsPablo Stanley Körner Mason
Easily handles phylogenetic analyses, though interface could improve.
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